Structure of PDB 2zw9 Chain B

Receptor sequence
>2zw9B (length=664) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
YADLAIQGTNNSSIASKRSVELLYLPKLSSANNFQMDKNNKLLEYFKFFV
PKKIKRSPCINRGYWLRLFAIRSRLNSIIEQTPQDKKIVVVNLGCGYDPL
PFQLLDTNNIQSQQYHDRVSFIDIDYSDLLKIKIELIKTIPELSKIIGLS
NVDFLTTPKYLARPCDLNDSKMFSTLLNECQLYDPNVVKVFVAEVSLAYM
KPERSDSIIEATSKMENSHFIILEQLIPKGPFEPFSKQMLAHFKRNDSPL
QSVLKYNTIESQVQRFNKLGFAYVNVGDMFQLWESADEATKKELLKVEPF
DELEEFHLFCHHYVLCHATNYKEFAFTQGFLFDRSISEINLTVDEDYQLL
ECECPINRKFGDVDVAGNDVFYMGGSNPYRVNEILQLSIHYDKIDMKNIE
VSSSEVPVARMCHTFTTISRNNQLLLIGGRKAPHQGLSDNWIFDMKTREW
SMIKSLSHTRFRHSACSLPDGNVLILGGVTEGPAMLLYNVTEEIFKDVTP
KDEFFQNSLVSAGLEFDPVSKQGIILGGGFMDQTTVSDKAIIFKYDAENA
TEPITVIKKLQHPLFQRYGSQIKYITPRKLLIVGGTSPSGLFDRTNSIIS
LDPLSETLTSIPISRRIWEDHSLMLAGFSLVSTSMGTIHIIGGGATCYGF
GSVTNVGLKLIAIA
3D structure
PDB2zw9 Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.290: tRNA(Phe) [7-(3-amino-3-carboxypropyl)wyosine(37)-O]-methyltransferase.
2.3.1.231: tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}- methoxycarbonyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B I27 T30 N31 S34 K38 G115 C116 D146 Y147 C195 L197 E224 V225 I6 T9 N10 S13 K17 G94 C95 D125 Y126 C165 L167 E194 V195
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0031591 wybutosine biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zw9, PDBe:2zw9, PDBj:2zw9
PDBsum2zw9
PubMed19287006
UniProtQ08282|TYW4_YEAST tRNA wybutosine-synthesizing protein 4 (Gene Name=PPM2)

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