Structure of PDB 2znq Chain B

Receptor sequence
>2znqB (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
MPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGAPFVIHDIETLWQAE
KGLVWLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQV
TLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIE
PKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILR
ALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSL
HPLLQEIYKD
3D structure
PDB2znq Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
ChainB
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B7G B V315 L318 K319 E471 K474 V100 L103 K104 E256 K259
BS02 401 B R284 C285 T288 T289 H323 F327 V341 V348 K367 H449 M453 L469 Y473 R69 C70 T73 T74 H108 F112 V126 V133 K152 H234 M238 L254 Y258 BindingDB: EC50=12nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2znq, PDBe:2znq, PDBj:2znq
PDBsum2znq
PubMed19622862
UniProtQ03181|PPARD_HUMAN Peroxisome proliferator-activated receptor delta (Gene Name=PPARD)

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