Structure of PDB 2zmf Chain B

Receptor sequence
>2zmfB (length=172) Species: 9606 (Homo sapiens) [Search protein sequence]
ELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNK
ELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAY
ADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTD
ENNFKMFAVFCALALHCANMYH
3D structure
PDB2zmf Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CMP B R286 C287 F304 D305 F324 G329 I330 A331 F352 N353 V356 Y362 T364 Q383 R39 C40 F57 D58 F77 G82 I83 A84 F105 N106 V109 Y115 T117 Q136
External links
PDB RCSB:2zmf, PDBe:2zmf, PDBj:2zmf
PDBsum2zmf
PubMed18477562
UniProtQ9Y233|PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Gene Name=PDE10A)

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