Structure of PDB 2zdx Chain B

Receptor sequence
>2zdxB (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
VPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANIL
KEIDILPTQLVTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTL
IKVRNRHHNVVPTMAQGIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRM
LMNQHILIFSDQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSS
PELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPS
LTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYYGLPISRLYAKYF
QGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHDWC
3D structure
PDB2zdx Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4.
ChainB
Resolution2.54 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H250 E254 K257 N258
Catalytic site (residue number reindexed from 1) H228 E232 K235 N236
Enzyme Commision number 2.7.11.2: [pyruvate dehydrogenase (acetyl-transferring)] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4A B N258 A262 D293 G297 V298 L306 L350 T358 N236 A240 D271 G275 V276 L284 L306 T314
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006885 regulation of pH
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565 regulation of cellular ketone metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0016310 phosphorylation
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0045124 regulation of bone resorption
GO:0046320 regulation of fatty acid oxidation
GO:0071398 cellular response to fatty acid
GO:0072593 reactive oxygen species metabolic process
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zdx, PDBe:2zdx, PDBj:2zdx
PDBsum2zdx
PubMed21904029
UniProtQ16654|PDK4_HUMAN [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (Gene Name=PDK4)

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