Structure of PDB 2za3 Chain B

Receptor sequence
>2za3B (length=316) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKE
KYINNVSIKKDILLKAPDNIIRKSEEFFYFFNHFCFYIINETNKYALTFK
MNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYRKF
IFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSAIF
QKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMNYI
RTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNPYP
QKAAQMYYDQINAILK
3D structure
PDB2za3 Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase
ChainB
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P B D23 K102 N104 D136 T194 T195 P264 G293 R294 D23 K100 N102 D134 T192 T193 P262 G291 R292 PDBbind-CN: -logKd/Ki=3.68,Ki=210uM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2za3, PDBe:2za3, PDBj:2za3
PDBsum2za3
PubMed17981823
UniProtQ8T6J6

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