Structure of PDB 2z4y Chain B

Receptor sequence

>2z4yB (length=282) Species: 4932 (Saccharomyces cerevisiae)

NKMEAKIDELINNDPVWSSQNESLISKPYNHILLIVQINRVMNLPKDQLA
IVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYMYF
RAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPT
QEMYLNMVMNKTGGLFRLTLRLMEALSPSSLVPFINLLGIIYQIRDDYLN
LKDFGFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSDKD
IKLKLIQILEFDTNSLAYTKNFINQLVNMIKN

3D structure

• PDB: 2z4y Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
• Chain: B
• Resolution: 2.1 Å

Enzymatic activity

• Enzyme Commision number: 2.5.1.-
  2.5.1.1: dimethylallyltranstransferase.
  2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
  2.5.1.29: geranylgeranyl diphosphate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	252	B	S76 D80 R89 L143 H144 Q147 K174 Q211 D214 K238	S63 D67 R76 L130 H131 Q134 K161 Q193 D196 K214	MOAD: ic50=0.71uM PDBbind-CN: -logKd/Ki=6.15,IC50=0.71uM

Gene Ontology

Molecular Function

• GO:0004161 dimethylallyltranstransferase activity
• GO:0004311 farnesyltranstransferase activity
• GO:0004337 geranyltranstransferase activity
• GO:0004659 prenyltransferase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0008299 isoprenoid biosynthetic process
• GO:0015031 protein transport
• GO:0016114 terpenoid biosynthetic process
• GO:0033384 geranyl diphosphate biosynthetic process
• GO:0033386 geranylgeranyl diphosphate biosynthetic process
• GO:0045337 farnesyl diphosphate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:2z4y, PDBe:2z4y, PDBj:2z4y
• PDBsum: 2z4y
• PubMed: 18800762
• UniProt: Q12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)