Structure of PDB 2z4w Chain B

Receptor sequence
>2z4wB (length=296) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NKMEAKIDELINNDPVWSSQNESLISKPYNHILLFRLNLIVQINRVMNLP
KDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTA
NYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLP
EIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQI
RDDYLNLKDFQFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLL
RTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIKNDNENKYLP
3D structure
PDB2z4w Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
ChainB
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
2.5.1.29: geranylgeranyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D80 D84 D72 D76
BS02 MG B D80 D84 D72 D76
BS03 749 B H73 S76 D80 R89 L143 Q147 K174 F179 Y210 D214 K238 H65 S68 D72 R81 L135 Q139 K166 F171 Y198 D202 K220 MOAD: ic50=0.98uM
PDBbind-CN: -logKd/Ki=6.01,IC50=0.98uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0015031 protein transport
GO:0016114 terpenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2z4w, PDBe:2z4w, PDBj:2z4w
PDBsum2z4w
PubMed18800762
UniProtQ12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)

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