Structure of PDB 2yy8 Chain B

Receptor sequence
>2yy8B (length=174) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
MIVVLRLGHRPERDKRVTTHVALTARAFGADGIIIASEEDEKVKESVEDV
VKRWGGPFFIEFNRNWRKVMKEFTGVKVHLTMYGLHVDDVIEELKEKLKK
GEDFMIIVGAEKVPREVYELADYNVAIGNQPHSEVAALAVLLDRLLEGKG
LKKEFKGAKIKIVPQARGKKVVEV
3D structure
PDB2yy8 Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA
ChainB
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.206: tRNA (cytidine(56)-2'-O)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM B L80 T81 M82 V108 G109 A110 K112 V113 I127 G128 H132 E134 A137 L80 T81 M82 V108 G109 A110 K112 V113 I127 G128 H132 E134 A137
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008175 tRNA methyltransferase activity
GO:0106059 tRNA (cytidine(56)-2'-O)-methyltransferase activity
Biological Process
GO:0002128 tRNA nucleoside ribose methylation
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2yy8, PDBe:2yy8, PDBj:2yy8
PDBsum2yy8
PubMed18068186
UniProtO58214|TRM56_PYRHO tRNA (cytidine(56)-2'-O)-methyltransferase (Gene Name=PH0461)

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