Structure of PDB 2yr6 Chain B

Receptor sequence

>2yr6B (length=684) Species: 266807 (Pseudomonas sp. P-501)

KIATTVGEARLSGINYRHPDSALVSYPVAAAAPLGRLPAGNYRIAIVGGG
AGGIAALYELGRLAATLPAGSGIDVQIYEADPDSFLHDRAIKVRGLKAGR
VSAALVHNGDPASGDTIYEVGAMRFPEIAGLTWHYASAAFGDAAPIKVFP
NPGKVPTEFVFGNRVDRYVGSDPKDWEDPDSPTLKVLGVVAGGLVGNPQG
ENVAMYPIANVDPAKIAAILNAATPPADALERIQTKYWPEFIAQYDGLTL
GAAVREIVTVAFEKGTLPPVDGVLDVDESISYYVELFGRFGFGTGGFKPL
YNISLVEMMRLILWDYSNEYTLPVTENVEFIRNLFLKAQNVGAGKLVVQV
RQERVANACHSGTASARAQLLSYDSHNAVHSEAYDFVILAVPHDQLTPIV
SRSGFEHAASQNLGDAGLGLETHTYNQVYPPLLLSDSSPAANARIVTAIG
QLHMARSSKVFATVKTAALDQPWVPQWRGEPIKAVVSDSGLAASYVVPSP
IVAPEYSSLLASYTWEDDSTRLRHDFGLYPQNPATETGTADGMYRTMVNR
AYRYVKYAGASNAQPWWFYQLLAEARTADRFVFDWTTNKTAGGFKLDMTG
DHHQSNLCFRYHTHALAASLDNRFFIASDSYSHLGGWLEGAFMSALNAVA
GLIVRANRGDVSALSTEARPLVIGLRPVVKVPAA

3D structure

• PDB: 2yr6 Structural basis of proteolytic activation of L-phenylalanine oxidase from Pseudomonas sp. P-501.
• Chain: B
• Resolution: 1.35 Å

Enzymatic activity

• Enzyme Commision number: 1.13.12.9: phenylalanine 2-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	G63 G65 G67 E94 A95 G118 R119 G140 A141 M142 R143 F144 R373 V374 V410 P411 Q414 W608 G616 S651 D652 G659 W660 L661	G48 G50 G52 E79 A80 G99 R100 G121 A122 M123 R124 F125 R354 V355 V391 P392 Q395 W585 G593 S628 D629 G636 W637 L638
BS02	BE2	B	R143 T313 F316 W538 F617 G659 W660	R124 T294 F297 W515 F594 G636 W637	MOAD: Ki=0.87mM

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004497 monooxygenase activity
• GO:0050172 phenylalanine 2-monooxygenase activity

External links

• PDB: RCSB:2yr6, PDBe:2yr6, PDBj:2yr6
• PDBsum: 2yr6
• PubMed: 18417467
• UniProt: Q5W9R9|PAO_PSESP Phenylalanine 2-monooxygenase precursor