Structure of PDB 2ypp Chain B

Receptor sequence
>2yppB (length=459) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MNWTVDIPIPSLPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLE
SVPPVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNV
RALLQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMIN
GFAPDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNRE
FVRTSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLD
YERAMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPV
GVKLGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEK
VQATGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGT
HPGGIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELA
FLVAEMLRD
3D structure
PDB2ypp Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR B V55 Y173 A174 V52 Y170 A171 MOAD: Kd=39uM
PDBbind-CN: -logKd/Ki=4.41,Kd=39uM
BS02 MN B C87 H369 E411 D441 C84 H366 E408 D438
BS03 TYR B F91 R171 A174 N175 F88 R168 A171 N172 MOAD: Kd=39uM
PDBbind-CN: -logKd/Ki=4.41,Kd=39uM
BS04 TYR B L15 P16 L18 R23 E53 R256 L12 P13 L15 R20 E50 R253 MOAD: Kd=39uM
PDBbind-CN: -logKd/Ki=4.41,Kd=39uM
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ypp, PDBe:2ypp, PDBj:2ypp
PDBsum2ypp
PubMed23274137
UniProtO53512|AROG_MYCTU Phospho-2-dehydro-3-deoxyheptonate aldolase AroG (Gene Name=aroG)

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