Structure of PDB 2yoh Chain B

Receptor sequence
>2yohB (length=199) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
DDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIG
QIISKYLKMENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAY
SGVAYSSGALNLNKTWCMNPDQGLIKPDVVFYLNVPPNYAIYEKVETQKK
IYETYKHFAHEDYWINIDATRKIEDIHNDIVKEVTKIKVEPEEFNFLWS
3D structure
PDB2yoh Synthesis and Evaluation of Alpha-Thymidine Analogues as Novel Antimalarials.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.8: guanylate kinase.
2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WMJ B F44 P45 L59 K60 F74 R78 R99 S103 G104 Y107 F42 P43 L57 K58 F72 R76 R97 S101 G102 Y105 MOAD: Ki=11uM
BindingDB: Ki=11000nM
Gene Ontology
Molecular Function
GO:0004385 guanylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0050316 T2-induced deoxynucleotide kinase activity
Biological Process
GO:0006177 GMP biosynthetic process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046710 GDP metabolic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2yoh, PDBe:2yoh, PDBj:2yoh
PDBsum2yoh
PubMed23240776
UniProtQ8I4S1|KTHY_PLAF7 Thymidylate kinase (Gene Name=TMK)

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