Structure of PDB 2yja Chain B

Receptor sequence
>2yjaB (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL
AQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL
3D structure
PDB2yja Design and Structure of Stapled Peptides Binding to Estrogen Receptors.
ChainB
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S305 I358 K362 L372 V376 E380 E542 M543 S1 I54 K58 L68 V72 E76 E238 M239
BS02 EST B E353 L387 F404 M421 H524 L525 E49 L83 F100 M117 H220 L221 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:2yja, PDBe:2yja, PDBj:2yja
PDBsum2yja
PubMed21612236
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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