Structure of PDB 2yem Chain B

Receptor sequence
>2yemB (length=111) Species: 9606 (Homo sapiens) [Search protein sequence]
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM
DMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQD
VFEMRFAKMPD
3D structure
PDB2yem Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSH B W374 P375 L387 N433 H437 V439 W26 P27 L39 N85 H89 V91 MOAD: ic50=15.5nM
BindingDB: Kd=19nM,IC50=15.5nM
External links
PDB RCSB:2yem, PDBe:2yem, PDBj:2yem
PDBsum2yem
PubMed21568322
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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