Structure of PDB 2yek Chain B

Receptor sequence
>2yekB (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]
TNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGT
IKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQ
KVASMPQ
3D structure
PDB2yek Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EAM B W97 P98 V103 L110 N156 I162 W22 P23 V28 L35 N81 I87 MOAD: ic50=32.5nM
BindingDB: IC50=32.5nM,Ki=74nM,Kd=100nM
External links
PDB RCSB:2yek, PDBe:2yek, PDBj:2yek
PDBsum2yek
PubMed21568322
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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