Structure of PDB 2ydw Chain B

Receptor sequence
>2ydwB (length=105) Species: 9606 (Homo sapiens) [Search protein sequence]
NQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTI
KRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQK
VASMP
3D structure
PDB2ydw Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WSH B W97 P98 V103 L108 L110 Y155 N156 I162 W21 P22 V27 L32 L34 Y79 N80 I86 MOAD: Kd=46nM
PDBbind-CN: -logKd/Ki=7.34,Kd=46.0nM
BindingDB: Kd=52nM,IC50=29.9nM
External links
PDB RCSB:2ydw, PDBe:2ydw, PDBj:2ydw
PDBsum2ydw
PubMed21568322
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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