Structure of PDB 2yb0 Chain B

Receptor sequence
>2yb0B (length=263) Species: 5664 (Leishmania major) [Search protein sequence]
KRARSANIPGAILHSLAELQDGLNAMIDPSWRAVRSLDNWALAITMESTE
LLDSYPWKWWKNLNATPDLANVRIELVDIFHFSLSGAMQMRSTPDDEIPA
ASLKPLKEVMTTFLPAKECTSDPYGFVFFPLTDTQNAIASFRNIIQLANA
YRFDVIIECIIYAAEDLGFNLVAYYIAKHTLNCIRQLSGYKDGSYVKVNN
GVEDNSLLHNCIKDVSLDEVLDADKYVQAWNSIMANVYEAFQIKESDRKD
AERWFALAKENRL
3D structure
PDB2yb0 The Crystal Structure of the Leishmania Major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, Dump, and Deoxyuridine.
ChainB
Resolution2.28 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUR B W60 W61 W59 W60 MOAD: Kd=140uM
PDBbind-CN: -logKd/Ki=3.85,Kd=140uM
BS02 DUR B N25 I28 D79 H82 F83 N183 N24 I27 D78 H81 F82 N182 MOAD: Kd=140uM
PDBbind-CN: -logKd/Ki=3.85,Kd=140uM
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:2yb0, PDBe:2yb0, PDBj:2yb0
PDBsum2yb0
PubMed21454646
UniProtO15826

[Back to BioLiP]