Structure of PDB 2xzi Chain B

Receptor sequence
>2xziB (length=384) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
DPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRIL
AFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGTW
GNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRRH
LYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIPA
MGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGYR
MVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTSR
RAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGAL
VESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN
3D structure
PDB2xzi The Aspergillus Fumigatus Sialidase is a Kdnase: Structural and Mechanistic Insights.
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KDM B R59 D84 Q148 E249 R265 R322 Y358 R37 D62 Q126 E227 R243 R300 Y336
BS02 KDM B S321 R322 R323 D376 S299 R300 R301 D354
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xzi, PDBe:2xzi, PDBj:2xzi
PDBsum2xzi
PubMed21247893
UniProtQ4WQS0|SIA_ASPFU Exo-alpha-sialidase (Gene Name=AFUA_4G13800)

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