Structure of PDB 2xue Chain B

Receptor sequence
>2xueB (length=423) Species: 9606 (Homo sapiens) [Search protein sequence]
LNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFS
TKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKY
AQYQASSFQESLHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTG
NMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEW
FAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGD
LVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKS
IVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKK
IAYQGRVKDEPAYYCNECDVEVFNILFVTSNTYLVHCEGCARRRSAGLQG
VVVLEQYRTEELAQAYDAFTLAP
3D structure
PDB2xue A Selective Jumonji H3K27 Demethylase Inhibitor Modulates the Proinflammatory Macrophage Response
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C1575 C1578 C1602 C1605 C365 C368 C387 C390
BS02 FE B H1390 E1392 H1470 H180 E182 H260
BS03 AKG B K1381 T1387 H1390 E1392 S1398 N1400 H1470 K171 T177 H180 E182 S188 N190 H260
External links
PDB RCSB:2xue, PDBe:2xue, PDBj:2xue
PDBsum2xue
PubMed22842901
UniProtO15054|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)

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