Structure of PDB 2xta Chain B

Receptor sequence
>2xtaB (length=814) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
DKNARVIELIAAYRNRGHLMADIDPLRLDNTRFRTLWDLDREFKVVQRKK
LRDILSVLRDAYCRHVGVEYTHILEPEQQRWIQERVETKHDKPTVAEQKY
ILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQCAEHGLD
EVVIAMPHRGRLNVLANIVGKPYSQIFSEDVKYHLGATGTYIQMFGDNDI
EVSLTANPSHLEAVDPVLEGLVRAKQDLLDTGEEGSDNRFSVVPLMLHGD
AAFAGQGVVAETLNLALLRGYRTGGTIHIVVNNQIGFTTAPTDSRSSEYC
TDVAKMIGAPIFHVNGDDPEACAWVARLAVDFRQAFKKDVVIDMLCYRRR
GHNEGDDPSMTQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEAEDALRD
YQGQLERVFNEVRELEKLATAVDKAMLQRIGDAHLALPEGFTVHPRVRPV
LEKRREMAYEGRIDWAFAELLALGSLIAEGKLVRLSGQDTQRGTFTQRHA
VIVDRKTGEEFTPLQLLATNPDGTPTGGKFLVYNSALSEFAAVGFEYGYS
VGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVLLLPHGH
EGQGPDHTSGRIERFLQLWAEGSMTIAMPSTPANYFHLLRRHGKDGIQRP
LIVFTPKSMLRNKAAVSDIRDFTESKFRSVLEEPMYTDGEGDRNKVTRLL
LTSGKIYYELAARKAKENREDVAIVRIEQLAPLPRRRLAETLDRYPNVKE
KFWVQEEPANQGAWPSFGLTLPEILPDHFTGLKRISRRAMSAPSSGSSKV
HAVEQQEILDTAFG
3D structure
PDB2xta Functional Plasticity and Allosteric Regulation of Alpha-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP B Q901 L950 E952 Q976 F980 Q488 L537 E539 Q563 F567
BS02 TPP B R540 S604 L606 G644 D645 A646 A647 Q651 N678 I680 H747 R159 S209 L211 G249 D250 A251 A252 Q256 N283 I285 H352
BS03 MG B D645 N678 I680 D250 N283 I285
BS04 CA B D1004 H1055 D1058 I1060 D591 H642 D645 I647
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:2xta, PDBe:2xta, PDBj:2xta
PDBsum2xta
PubMed21867916
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

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