Structure of PDB 2xrc Chain B

Receptor sequence
>2xrcB (length=485) Species: 9606 (Homo sapiens) [Search protein sequence]
DLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCA
TNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGNTDSEGI
VEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSI
NSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTFFQCVNGKYI
SQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCI
TGEDEVGCLTADMDAERRRIKSLLPKLSCIVGGKRAQLGDLPWQVAIKDA
SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTRIVIEYVDRIIFHENY
NAGTYQNDIALIEMKCELPRSIPACVPWSPYLFQPNDTCIVSGWLQWGEV
KLISNCSKFYGNRFYEKEMECAGTYDSGGPLVCMDANNVTYVWGVVSWGE
NCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV
3D structure
PDB2xrc Structural Basis for Complement Factor I Control and its Disease-Associated Sequence Polymorphisms.
ChainB
Resolution2.69 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H362 D411 D506 S507 G508
Catalytic site (residue number reindexed from 1) H320 D358 D426 S427 G428
Enzyme Commision number 3.4.21.45: complement factor I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B Y258 N261 E263 D265 D271 E272 Y241 N244 E246 D248 D254 E255
BS02 CA B K221 D224 I226 D228 D234 E235 K204 D207 I209 D211 D217 E218
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0045087 innate immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2xrc, PDBe:2xrc, PDBj:2xrc
PDBsum2xrc
PubMed21768352
UniProtP05156|CFAI_HUMAN Complement factor I (Gene Name=CFI)

[Back to BioLiP]