Structure of PDB 2xoz Chain B

Receptor sequence
>2xozB (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
YVVCRQCPEYRRQAAQPPHCPDYVCPLQGSHALCTCCFQPMPDRRVEREQ
DPRVAPQQCAVCLQPFCHLYWGCTRTGCYGCLAPFCELNLGDKCLDGVLN
NNSYESDILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGDTVLC
YCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCYWGRNCRTQVKAHHAM
KFNHICEQTRFK
3D structure
PDB2xoz Structural Basis of Poly(Adp-Ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-Associated and Ring Domains (Chfr).
ChainB
Resolution2.374 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C428 C476 H482 C4 C25 H31
BS02 ZN B C485 C488 C518 C524 C34 C37 C67 C73
BS03 ZN B C487 C524 C529 C532 C36 C73 C78 C81
BS04 ZN B C510 C513 C601 C604 C59 C62 C150 C153
BS05 ZN B C635 C641 H649 H655 C184 C190 H198 H204
BS06 AMP B C635 Y636 F653 C184 Y185 F202
BS07 AMP B W637 C641 R642 T643 W186 C190 R191 T192
External links
PDB RCSB:2xoz, PDBe:2xoz, PDBj:2xoz
PDBsum2xoz
PubMed20880844
UniProtQ96EP1|CHFR_HUMAN E3 ubiquitin-protein ligase CHFR (Gene Name=CHFR)

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