Structure of PDB 2xoy Chain B

Receptor sequence

>2xoyB (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]

YVVCRQCPEYRRQAAQPPHCPADYVCPLQGSHALCTCCFQPMPDRRVERE
QDPRVAPQQCAVCLQPFCHLYWGCTRTGCYGCLAPFCELNLGDKCLDGVL
NNNSYESDILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGDTVL
CYCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCYWGRNCRTQVKAHHA
MKFNHICEQTRFKN

3D structure

PDB

2xoy Structural Basis of Poly(Adp-Ribose) Recognition by the Multizinc Binding Domain of Checkpoint with Forkhead-Associated and Ring Domains (Chfr).

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	B	C428 C431 C476 H482	C4 C7 C26 H32
BS02	ZN	B	C485 C488 C518 C524	C35 C38 C68 C74
BS03	ZN	B	C487 C524 C529 C532	C37 C74 C79 C82
BS04	ZN	B	C510 C513 C601 C604	C60 C63 C151 C154
BS05	ZN	B	C635 C641 H649 H655	C185 C191 H199 H205
BS06	AMP	B	W637 C641 R642 R661 K663 N664	W187 C191 R192 R211 K213 N214
BS07	ADE	B	C635 Y636 F653	C185 Y186 F203

External links

PDB	RCSB:2xoy, PDBe:2xoy, PDBj:2xoy
PDBsum	2xoy
PubMed	20880844
UniProt	Q96EP1\|CHFR_HUMAN E3 ubiquitin-protein ligase CHFR (Gene Name=CHFR)

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