Structure of PDB 2xh9 Chain B

Receptor sequence
>2xh9B (length=427) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
VPTPAEAALAAQTALAADDSPMGDAARWAMGLLTSSGLPRPEDVAARFIP
TFAAANFAETVREWRSKGPFTVRAYHPVAHKGWVVLSAPAGVRYILSLTL
DSSGLIRILTLKPETVIPDMVTWNDVEETLHTPGVQHSVYAVRLTPDGHE
VLHASAPERPMPTGSAYKLYLMRALVAEIEKGTVGWDEILTLTPELRSLP
TGDMQDLPDGTRVTVRETAHKMIALSDNTGADLVADRLGREVVERSLAAA
GHHDPSLMRPFLTSHEVFELGWGDPERRAEWVRQDEAGRRELLEKMAGVM
TVRGSDLGATVHQLGIDWHMDAFDVVRVLEGLLQDSGRDTSGTVEEILTA
YPGLLIDEERWRRVYFKAGASPGVMMFCWLLQDHAGISYVLVLRQSADEQ
RLIGDGLFLRGIGAKIIEAEAKLLSSG
3D structure
PDB2xh9 Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J01 B H84 V93 L362 R418 A422 H76 V85 L354 R410 A414
BS02 J01 B K89 S234 Y359 A376 F385 R418 K81 S226 Y351 A368 F377 R410
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2xh9, PDBe:2xh9, PDBj:2xh9
PDBsum2xh9
PubMed23897479
UniProtQ8KRB7

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