Structure of PDB 2xbu Chain B

Receptor sequence
>2xbuB (length=202) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DKQYISYNNVHQLCQVSAERIKNFKPDLIIAIGGGGFIPARILRTFLKEP
GVPTIRIFAIILSLYEDLVKVSRTQWIDYEQCKLDLVGKNVLIVDEVDDT
RTTLHYALSELEKDAAEQAKAKGIDTEKSPEMKTNFGIFVLHDKQKPKKA
DLPAEMLNDKNRYFAAKTVPDKWYAYPWESTDIVFHTRMAIEQGNDIFIP
EQ
3D structure
PDB2xbu Functional Significance of Four Successive Glycine Residues in the Pyrophosphate Binding Loop of Fungal 6-Oxopurine Phosphoribosyltransferases.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B I36 G39 D110 E111 I32 G35 D95 E96
BS02 5GP B V112 D114 T115 R116 T117 T118 K159 W188 Y189 Y191 E194 V97 D99 T100 R101 T102 T103 K144 W173 Y174 Y176 E179
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0009058 biosynthetic process
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0032265 XMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xbu, PDBe:2xbu, PDBj:2xbu
PDBsum2xbu
PubMed22610485
UniProtQ04178|HPRT_YEAST Hypoxanthine-guanine phosphoribosyltransferase (Gene Name=HPT1)

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