Structure of PDB 2xao Chain B

Receptor sequence
>2xaoB (length=424) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
EMILEEKDASDWIYRGEGGANLVLAYAGSSPLFVGKVIRIQKARRNDKAI
KVSVLTSDEQHLWRENNELISSPNKEVLEQRYVQNVIIPLLGPKHVDAGV
RVSVSKEFLECVDKKVTKQRPLWRVNAANVDTSHDSALILNDHSLFSDCI
SVEIKPKCGFLPTSRFIGKENMLKTSVSRFKMHQLLKLEYIEISEESEYD
PLDLFSGSKERVLEAIKALYSTPQNNFRVFLNGSLILGGSGESTGRTSPE
IGYAFEDALKGFIQSEDGHRTECFLQLVSDAVYGSGVLDRLLEIQKLDKL
DIEGAIHCYYDIINQPCPICKEGRPLEAELSLHALPLDESLKIVKEYLIA
ATAKDCSIMISFQSRNAWDSEPSGDYVSLKPTNQTFDYKVHFIDLSLKPL
KRMESYYKLDKKIISFYNRKQKAE
3D structure
PDB2xao Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase is a Distant Ipk Member with a Singular Inositide Binding Site for Axial 2-Oh Recognition.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.158: inositol-pentakisphosphate 2-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5MY B G20 R45 R130 K168 K170 H196 K200 D368 K411 R415 Y419 G19 R44 R124 K155 K157 H183 K187 D355 K398 R402 Y406
BS02 ZN B H320 C330 C333 H346 H307 C317 C320 H333
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0032942 inositol-1,4,5,6-tetrakisphosphate 2-kinase activity
GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity
GO:0046872 metal ion binding
GO:0102731 inositol-1,3,4,6-tetrakisphosphate 2-kinase activity
Biological Process
GO:0010264 myo-inositol hexakisphosphate biosynthetic process
GO:0016310 phosphorylation
GO:0030643 intracellular phosphate ion homeostasis
GO:0042742 defense response to bacterium
GO:0048527 lateral root development
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0055062 phosphate ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xao, PDBe:2xao, PDBj:2xao
PDBsum2xao
PubMed20453199
UniProtQ93YN9|IPPK_ARATH Inositol-pentakisphosphate 2-kinase (Gene Name=IPK1)

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