Structure of PDB 2x6k Chain B

Receptor sequence
>2x6kB (length=550) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
ASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCIN
WKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAP
DEDLLLYLLQLVQALKYEDPRHIVHLHGCIFPEANLCTFLIQRACTNATL
ANYFYWYLSIEVEEVERKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFY
NLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNF
EPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKH
GDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDS
CTVAEVLAREGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITY
LLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSKEMVEAM
GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDK
AVKKVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK
3D structure
PDB2x6k Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X6K B K674 K698 D706 Y732 L744 Q745 Y746 V747 I822 K275 K299 D307 Y333 L345 Q346 Y347 V348 I423
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2x6k, PDBe:2x6k, PDBj:2x6k
PDBsum2x6k
PubMed20339072
UniProtQ9W1M7

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