Structure of PDB 2x0u Chain B

Receptor sequence
>2x0uB (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
VPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLW
VDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIR
VEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMGGM
NRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLR
3D structure
PDB2x0u Toward the Rational Design of P53-Stabilizing Drugs: Probing the Surface of the Oncogenic Y220C Mutant.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X0U B V147 T150 P151 C220 V51 T54 P55 C124
BS02 ZN B C176 H179 C238 C242 C80 H83 C142 C146
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2x0u, PDBe:2x0u, PDBj:2x0u
PDBsum2x0u
PubMed20142040
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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