Structure of PDB 2wtu Chain B

Receptor sequence
>2wtuB (length=738) Species: 562 (Escherichia coli) [Search protein sequence]
FYELFYDDAKRASQLLDISPMAGIPYHAVENYLAKLVNQGESVAICEVVR
IVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPAD
RETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQ
LNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMER
EQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLH
MPVRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARP
RDLARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAII
DTPPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDT
LKVGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDK
VLTSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERA
YTLNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLII
TGPNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGAADD
LASGRSTFMVEMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACA
ENLANKIKALTLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSV
QDGAASKSYGLAVAALAGVPKEVIKRARQKLRELESIS
3D structure
PDB2wtu Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B D461 N468 L495 K496 R500 D399 N406 L433 K434 R438
BS02 dna B K464 S478 K402 S416
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wtu, PDBe:2wtu, PDBj:2wtu
PDBsum2wtu
PubMed20167596
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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