Structure of PDB 2wr2 Chain B

Receptor sequence
>2wr2B (length=490) Species: 11309 (unidentified influenza virus) [Search protein sequence]
DQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCRLSGIPPL
ELGDCSIAGWLLGNPECDRLLSVPEWSYIVEKENPVNGLCYPGSFNDYEE
LKHLITSVTHFEKVKILPRDQWTQHTTTGGSRACAVLDNPSFFRNMVLTK
KGSNYPIAKRSYNNTSGEQMLIIWGIHHPNDDAEQRTLYQNVGTYVSVGT
STLNKRSIPEIATRPKVNGQGGRMEFSWTLLETWDVINFESTGNLIAPEY
GFKISKRGSSGIMKTEKTLENCETKCQTPLGAINTTLPFHNIHPLTIGEC
PKYVKSDRLVLATGLRNVPQIGLFGAIAGFIEGGWQGMVDGWYGYHHSND
QGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFSNLERRLEN
LNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDN
VKELGNGCFEFYHKCDDECMNSVKNGTYDYPKYEEESKAA
3D structure
PDB2wr2 From the Cover: Structures of Receptor Complexes Formed by Hemagglutinins from the Asian Influenza Pandemic of 1957.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.53: sialate O-acetylesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA B Y95 G133 G134 S135 R136 H182 E189 L193 Q225 Y91 G129 G130 S131 R132 H177 E184 L188 Q220
Gene Ontology
Molecular Function
GO:0001681 sialate O-acetylesterase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046718 symbiont entry into host cell
GO:0046761 viral budding from plasma membrane
GO:0075512 clathrin-dependent endocytosis of virus by host cell
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wr2, PDBe:2wr2, PDBj:2wr2
PDBsum2wr2
PubMed19805083
UniProtD0VWP8

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