Structure of PDB 2wog Chain B

Receptor sequence
>2wogB (length=328) Species: 9606 (Homo sapiens) [Search protein sequence]
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYT
FDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEG
ERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEE
LFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKG
AAKRTTAATLMNAYSSRSHSVFSVTIHMKEGEELVKIGKLNLVDLAGSEN
NINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATI
SPASLNLEETLSTLEYAHRAKNILNKPE
3D structure
PDB2wog An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R24 R26 P27 T107 G108 G110 K111 T112 F113 E118 R7 R9 P10 T90 G91 G93 K94 T95 F96 E101
BS02 ZZD B E116 G117 E118 R119 A133 P137 Y211 L214 E215 R221 E99 G100 E101 R102 A116 P120 Y194 L197 E198 R204 BindingDB: IC50=1000nM,EC50=1720nM,Ki=143.8nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:2wog, PDBe:2wog, PDBj:2wog
PDBsum2wog
PubMed19793049
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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