Structure of PDB 2w8z Chain B

Receptor sequence
>2w8zB (length=467) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
AKHQIGVIGLAVMGKNLALNIESKGYSVAVYNRLREKTDEFLQEAKGKNI
VGTYSIEEFVNALEKPRKILLMVKAGAPTDATIEQLKPHLEKGDIVIDGG
NTYFKDTQRRNKELAELGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHEL
VRPIFEAIAAKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYF
LLKHVLGMDAAELHEVFADWNKGELNSYLIEITADIFTKIDEETGKPLVD
VILDKAGQKGTGKWTSQNALDLGVPLPIITESVFARFLSAMKDERVKASK
VLAGPAVKPFEGDRAHFIEAVRRALYMSKICSYAQGFAQMKAASEEYNWN
LRYGDIAMIFRGGCIIRAQFLQKIKEAYDRDPALSNLLLDSYFKDIVERY
QDALREIVATAAMRGIPVPGSASALAYYDSYRTAVLPANLIQAQRDYFGA
HTYERVDKEGIFHTEWL
3D structure
PDB2w8z Geobacillus Stearothermophilus 6-Phosphogluconate Dehydrogenase, Complexed with 6-Phosphogluconate.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S128 K182 H185 N186 E189
Catalytic site (residue number reindexed from 1) S127 K181 H184 N185 E188
Enzyme Commision number 1.1.1.44: phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6PG B R446 H452 R445 H451
BS02 6PG B S128 G130 K182 N186 E189 Y190 K260 I366 S127 G129 K181 N185 E188 Y189 K259 I365
Gene Ontology
Molecular Function
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0009051 pentose-phosphate shunt, oxidative branch
GO:0016054 organic acid catabolic process
GO:0019521 D-gluconate metabolic process
GO:0046177 D-gluconate catabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2w8z, PDBe:2w8z, PDBj:2w8z
PDBsum2w8z
PubMed19407374
UniProtI3NI58

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