Structure of PDB 2w0s Chain B

Receptor sequence
>2w0sB (length=203) Species: 10249 (Vaccinia virus Copenhagen) [Search protein sequence]
SRGALIVFEGLDKSGKTTQCMNIMESIPANTIKYLNFPQRSTVTGKMIDD
YLTRKKTYNDHIVNLLFCANRWEFASFIQEQLEQGITLIVDRYAFSGVAY
AAAKGASMTLSKSYESGLPKPDLVIFLESGSKEINRNVGEEIYEDVTFQQ
KVLQEYKKMIEEGDIHWQIISSEFEEDVKKELIKNIVIEAIHTVTGPVGQ
LWM
3D structure
PDB2w0s Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy
ChainB
Resolution2.918 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N37 D92 N36 D91
BS02 BVP B D13 R41 L53 N65 F68 R72 R93 G98 Y101 A102 Y144 D12 R40 L52 N64 F67 R71 R92 G97 Y100 A101 Y143
BS03 BVP B A70 W73 A69 W72
Gene Ontology
Molecular Function
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2w0s, PDBe:2w0s, PDBj:2w0s
PDBsum2w0s
PubMed18971333
UniProtP68693|KTHY_VACCC Thymidylate kinase (Gene Name=OPG178)

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