Structure of PDB 2vzw Chain B

Receptor sequence
>2vzwB (length=149) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GKLDATLRAIVHTAAELVDARYGALGVRGYDHRLVEFVYEGIDEETRHLI
GSLPEGRGVLGALIEEPKPIRLDDISRHPASVGFPLHHPPMRTFLGVPVR
IRDEVFGNLYLTEKADGQPFSDDDEVLVQALAAAAGIAVDNARLFEESR
3D structure
PDB2vzw 2.3 A X-Ray Structure of the Heme-Bound Gaf Domain of Sensory Histidine Kinase Dost of Mycobacterium Tuberculosis.
ChainB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B F96 R106 I109 S111 P113 E114 G115 G117 V118 S140 V141 F143 P144 H147 M150 Y169 F37 R47 I50 S52 P54 E55 G56 G58 V59 S81 V82 F84 P85 H88 M91 Y110
BS02 OXY B P113 Y169 P54 Y110
External links
PDB RCSB:2vzw, PDBe:2vzw, PDBj:2vzw
PDBsum2vzw
PubMed18980385
UniProtP9WGK1|DOST_MYCTU Oxygen sensor histidine kinase response regulator DosT (Gene Name=dosT)

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