Structure of PDB 2vzm Chain B

Receptor sequence
>2vzmB (length=394) Species: 54571 (Streptomyces venezuelae) [Search protein sequence]
PVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGNEVWLVVGYDRAR
AVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFT
MRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLG
VPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGED
LLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSH
PDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAG
DTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLARL
EARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWR
3D structure
PDB2vzm Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae.
ChainB
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D23 P47 F180 A243 E246 T247 T248 V290 C354 I355 G356 E363 I395
Catalytic site (residue number reindexed from 1) D11 P35 F168 A231 E234 T235 T236 V278 C342 I343 G344 E351 I383
Enzyme Commision number 1.14.15.33: pikromycin synthase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0033068 macrolide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2vzm, PDBe:2vzm, PDBj:2vzm
PDBsum2vzm
PubMed19124459
UniProtO87605|PIKC_STRVZ Cytochrome P450 monooxygenase PikC (Gene Name=pikC)

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