Structure of PDB 2vqo Chain B

Receptor sequence
>2vqoB (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
RFTTGLVYDTLMLKHAGRIQSIWSRLQETGLRGKCEAIRGRKATLEELQT
VHSEAHTLLYGTNPLDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELK
NGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDV
HHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVN
MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPT
PLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGYDLTAICDASEACVSA
LLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRS
LIEAQTCE
3D structure
PDB2vqo Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
ChainB
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TFG B L78 Y79 A124 L59 Y60 A77 MOAD: ic50=317nM
BS02 TFG B P156 H159 G167 F168 D196 H198 F227 L299 G330 P109 H112 G120 F121 D149 H151 F180 L252 G283 MOAD: ic50=317nM
BS03 ZN B D196 H198 D290 D149 H151 D243
External links
PDB RCSB:2vqo, PDBe:2vqo, PDBj:2vqo
PDBsum2vqo
PubMed18614528
UniProtP56524|HDAC4_HUMAN Histone deacetylase 4 (Gene Name=HDAC4)

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