Structure of PDB 2vl8 Chain B

Receptor sequence
>2vl8B (length=533) Species: 1505 (Paraclostridium sordellii) [Search protein sequence]
LVNKAQLQKMAYVKFRIQEDEYVAILNALEEYHNMSESSVVEKYLKLKDI
NNLTDNYLNTYKKSGRNKALKKFKEYLTMEVLELKNNSLTPVEKNLHFIW
IGGQINDTAINYINQWKDVNSDYTVKVFYDSNAFLINTLKKTIVESATNN
TLESFRENLNDPEFDYNKFYRKRMEIIYDKQKHFIDYYKSQIEENPEFII
DNIIKTYLSNEYSKDLEALNKYIEESLNKITANNGNDIRNLEKFADEDLV
RLYNQELVERWNLAAASDILRISMLKEDGGVYLDVDMLPGIQPDLFKSIN
KPDSITNTSWEMIKLEAIMKYKEYIPGYTSKNFDMLDEEVQRSFESALSS
KSDKSEIFLPLDDIKVSPLEVKIAFANNSVINQALISLKDSYCSDLVINQ
IKNRYKILNDNLNPSINEGTDFNTTMKIFSDKLASISNEDNMMFMIKITN
YLKVGFAPDVRSTINLSGPGVYTGAYQDLLMFKDNSTNIHLLEPELRNFE
FPKTKISQLTEQEITSLARAKSQFEEYKKGYFE
3D structure
PDB2vl8 Inhibition of the Glucosyltransferase Activity of Clostridial Rho/Ras-Glucosylating Toxins by Castanospermine.
ChainB
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP B I101 W102 I103 L265 S269 D286 I99 W100 I101 L263 S267 D284
BS02 CTS B D270 R273 D286 I383 N384 T465 D268 R271 D284 I381 N382 T463 MOAD: ic50~30uM
BS03 CA B D288 E515 S518 D286 E513 S516
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2vl8, PDBe:2vl8, PDBj:2vl8
PDBsum2vl8
PubMed18505687
UniProtQ46342|TCSL1_PARSO Cytotoxin-L (Gene Name=tcsL)

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