Structure of PDB 2vig Chain B

Receptor sequence

>2vigB (length=371) Species: 9606 (Homo sapiens) [Search protein sequence]

LPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMD
VPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSK
EQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTK
AWITNAWEASAAVVFASTSISAFLVPMPTPGLTLGKKEDKLGIRGSSTAN
LIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCA
VNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKP
FIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEI
YEGTSEIQRLVIAGHLLRSYR

3D structure

PDB

2vig Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	L154 S155 G271 E392 G404
Catalytic site (residue number reindexed from 1)	L121 S122 G231 E352 G364
Enzyme Commision number	1.3.8.1: short-chain acyl-CoA dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	B	R297 F300 L304 L307 Q365 I366 G369	R257 F260 L264 L267 Q325 I326 G329
BS02	FAD	B	L154 S155 G160 S161 W185 T187 I387 Y391 T394 E396	L121 S122 G127 S128 W152 T154 I347 Y351 T354 E356
BS03	COS	B	S161 F261 M265 Q266 L268 D269 R272 E392 G393 I397	S128 F221 M225 Q226 L228 D229 R232 E352 G353 I357

Gene Ontology

	Molecular Function
GO:0003995	acyl-CoA dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937	short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006631	fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359	butyrate catabolic process

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005813	centrosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2vig, PDBe:2vig, PDBj:2vig
PDBsum	2vig
PubMed
UniProt	P16219\|ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADS)

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