Structure of PDB 2vgp Chain B

Receptor sequence
>2vgpB (length=278) Species: 8355 (Xenopus laevis) [Search protein sequence]
TALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKS
QLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGE
LYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYK
GELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGV
LCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPPFLSDGSKDLISKLLRYH
PPQRLPLKGVMEHPWVKANSRRVLPPVY
3D structure
PDB2vgp Discovery of Selective Aminothiazole Aurora Kinase Inhibitors
ChainB
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D216 K218 E220 N221 D234 T252
Catalytic site (residue number reindexed from 1) D139 K141 E143 N144 D157 T175
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 AD6 B L99 F104 A173 G176 L223 L22 F27 A96 G99 L146 MOAD: ic50=577nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:2vgp, PDBe:2vgp, PDBj:2vgp
PDBsum2vgp
PubMed18307303
UniProtQ6DE08|AUKBA_XENLA Aurora kinase B-A (Gene Name=aurkb-a)

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