Structure of PDB 2vf7 Chain B

Receptor sequence

>2vf7B (length=813) Species: 1299 (Deinococcus radiodurans)

PDFPDGGFVQVRGARQHNLKDISVKVPRDALVVFTGVSGSGKSSLAFGTL
YAEAQRRYLESVSPYARRLFNQAGVPDVDAIDGLPPAVALQQARGTPTAR
SSVGSVTTLSNLLRMLYSRAGDYPPGQGIVYAEGFSPNTPEGACPECHGL
GRVYTVTEDSMVPDPSLTIRERAVAAWPQAWGGQNQRDILVTLGIDVDVP
WRELPEETRHWILFTDEQPVVPVYPGLTPAETQRALKKKMEPSYMGTFSS
ARRHVLHTFANTESASMKKRVQGYMISEECPLCHGKRLRQEALNVTFAGL
DITELSRLPLARVSELLRPYAEEREPGHAERVKNRPEQAIALQRMAADLV
KRLDVLLHLGLGYLGLDRSTPTLSPGELQRLRLATQLYSNLFGVVYVLDE
PSAGLHPADTEALLSALENLKRGGNSLFVVEHDLDVIRRADWLVDVGPEA
GEKGGEILYSGPPEGLKHVPESQTGQYLFADRHTEPHTPREPAGWLELNG
VTRNNLDNLDVRFPLGVMTSVTGVSGSGKSTLVSQALVDALAAHFGQGSA
RLGGDLAQITRLVRVDQKPIGRTPRSNMATYTGLFDQVRKLFAATPLAKK
RGYNAGRFSFNVKGGRCEHCQGEGWVMVPSVYAPCPVCHGTRYNAETLEV
EYRGKNIADVLALTVDEAHDFFADESAIFRALDTLREVGLGYLRLGQPAT
ELSGGEAQRIKLATELRRSGRGGTVYVLDEPTTGLHPADVERLQRQLVKL
VDAGNTVIAVEHKMQVVAASDWVLDIGPGAGEDGGRLVAQGTPAEVAQAA
GSVTAPYLRAALR

3D structure

• PDB: 2vf7 Structural and mutational analyses of Deinococcus radiodurans UvrA2 provide insight into DNA binding and damage recognition by UvrAs.
• Chain: B
• Resolution: 2.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	B	Y370 R375 N511 N512 G533 S534 G535 K536 S537 T538	Y363 R368 N504 N505 G526 S527 G528 K529 S530 T531
BS02	ADP	B	H24 N25 G46 S47 G48 K49 S50 S51 R101 Q726 E730	H17 N18 G39 S40 G41 K42 S43 S44 R94 Q697 E701
BS03	ZN	B	C151 C154 C287 C290	C144 C147 C280 C283
BS04	ZN	B	C641 C644 C664 C667	C617 C620 C635 C638

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0004518 nuclease activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006281 DNA repair
• GO:0006289 nucleotide-excision repair

Cellular Component

• GO:0005737 cytoplasm
• GO:0009380 excinuclease repair complex

External links

• PDB: RCSB:2vf7, PDBe:2vf7, PDBj:2vf7
• PDBsum: 2vf7
• PubMed: 19368888
• UniProt: Q9RYW8