Structure of PDB 2vc2 Chain B

Receptor sequence

>2vc2B (length=457) Species: 9606 (Homo sapiens) [Search protein sequence]

GPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCA
PESIEFPVSEARVLEDRPLSDKSSQVTQVSPQRIALRLRPDDSKNFSIQV
RQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFG
AFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFN
EEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKT
HIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNI
NLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSK
VELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVR
GCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGT
FECGVCR

3D structure

PDB

2vc2 Structural Basis for Distinctive Recognition of Fibrinogen Gammac Peptide by the Platelet Integrin Alphaiibbeta3.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	180	B	S121 Y122 S123 R214 N215 R216 D217 A218	S117 Y118 S119 R210 N211 R212 D213 A214	BindingDB: IC50=8.0nM
BS02	MG	B	S121 S123 E220	S117 S119 E216
BS03	CA	B	S123 D126 D127 D251	S119 D122 D123 D247
BS04	CA	B	D158 N215 D217 P219 E220	D154 N211 D213 P215 E216

External links

PDB	RCSB:2vc2, PDBe:2vc2, PDBj:2vc2
PDBsum	2vc2
PubMed	18710925
UniProt	P05106\|ITB3_HUMAN Integrin beta-3 (Gene Name=ITGB3)

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