Structure of PDB 2vbq Chain B

Receptor sequence
>2vbqB (length=144) [Search protein sequence]
DIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMAD
GVAIGFADASIRHDYVNGCDSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQ
RWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC
3D structure
PDB2vbq Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella Enterica Aminoglycoside 6'-N-Acetyltransferase.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.82: aminoglycoside 6'-N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BSJ B Y66 E136 Y65 E135 MOAD: Ki<41uM
BS02 BSJ B W22 H25 E79 G80 I81 F82 V83 R88 Q89 G91 A93 K94 D115 T116 I122 S123 V126 H127 A129 L130 W21 H24 E78 G79 I80 F81 V82 R87 Q88 G90 A92 K93 D114 T115 I121 S122 V125 H126 A128 L129 MOAD: Ki<41uM
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042803 protein homodimerization activity
GO:0047663 aminoglycoside 6'-N-acetyltransferase activity
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2vbq, PDBe:2vbq, PDBj:2vbq
PDBsum2vbq
PubMed18095712
UniProtQ9R381|AAC6_SALEN Aminoglycoside N(6')-acetyltransferase type 1

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