Structure of PDB 2vbi Chain B

Receptor sequence
>2vbiB (length=554) Species: 438 (Acetobacter pasteurianus) [Search protein sequence]
TYTVGMYLAERLVQIGLKHHFAVAGDYNLVLLDQLLLNKDMKQIYCCNEL
NCGFSAEGYARSNGAAAAVVTFSVGAISAMNALGGAYAENLPVILISGAP
NSNDQGTGHILHHTIGKTDYSYQLEMARQVTCAAESITDAHSAPAKIDHV
IRTALRERKPAYLDIACNIASEPCVRPGPVSSLLSEPEIDHTSLKAAVDA
TVALLEKSASPVMLLGSKLRAANALAATETLADKLQCAVTIMAAAKGFFP
EDHAGFRGLYWGEVSNPGVQELVETSDALLCIAPVFNDYSTVGWSAWPKG
PNVILAEPDRVTVDGRAYDGFTLRAFLQALAEKAPARPASAQKSSVPTCS
LTATSDEAGLTNDEIVRHINALLTSNTTLVAETGDSWFNAMRMTLPRGAR
VELEMQWGHIGWSVPSAFGNAMGSQDRQHVVMVGDGSFQLTAQEVAQMVR
YELPVIIFLINNRGYVIEIAIHDGPYNYIKNWDYAGLMEVFNAGEGHGLG
LKATTPKELTEAIARAKANTRGPTLIECQIDRTDCTDMLVQWGRKVASTN
ARKT
3D structure
PDB2vbi ?
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G26 D27 Y28 N29 E50 T72 H113 H114 I116 G117 C168 S291 T384 G409 I411 D436 N463 G465 Y466 I468 E469 R533
Catalytic site (residue number reindexed from 1) G25 D26 Y27 N28 E49 T71 H112 H113 I115 G116 C167 S290 T383 G408 I410 D435 N462 G464 Y465 I467 E468 R532
Enzyme Commision number 4.1.1.1: pyruvate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP B A25 E50 V75 A24 E49 V74
BS02 MG B D436 N463 G465 D435 N462 G464
BS03 TPP B G385 D386 G409 H410 I411 G435 D436 G437 S438 G465 Y466 V467 I468 G384 D385 G408 H409 I410 G434 D435 G436 S437 G464 Y465 V466 I467
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:2vbi, PDBe:2vbi, PDBj:2vbi
PDBsum2vbi
PubMed
UniProtQ8L388

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