Structure of PDB 2v54 Chain B

Receptor sequence
>2v54B (length=203) Species: 10249 (Vaccinia virus Copenhagen) [Search protein sequence]
SRGALIVFEGLDKSGKTTQCMNIMESIPANTIKYLNFPQRSTVTGKMIDD
YLTRKKTYNDHIVNLLFCANRWEFASFIQEQLEQGITLIVDRYAFSGVAY
AAAKGASMTLSKSYESGLPKPDLVIFLESGSKEINRNVGEEIYEDVTFQQ
KVLQEYKKMIEEGDIHWQIISSEFEEDVKKELIKNIVIEAIHTVTGPVGQ
LWM
3D structure
PDB2v54 Crystal Structure of Poxvirus Thymidylate Kinase: An Unexpected Dimerization Has Implications for Antiviral Therapy
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D13 E145 D12 E144
BS02 POP B K14 S15 G16 K17 T18 K13 S14 G15 K16 T17
BS03 TYD B D13 K17 R41 L53 F68 R72 R93 S97 G98 Y101 Y144 D12 K16 R40 L52 F67 R71 R92 S96 G97 Y100 Y143
Gene Ontology
Molecular Function
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2v54, PDBe:2v54, PDBj:2v54
PDBsum2v54
PubMed18971333
UniProtP68693|KTHY_VACCC Thymidylate kinase (Gene Name=OPG178)

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