Structure of PDB 2tps Chain B

Receptor sequence
>2tpsB (length=226) Species: 1423 (Bacillus subtilis) [Search protein sequence]
HHGIRMTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQF
REKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHI
GQEDANAKEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTET
KKDTRAVQGVSLIEAVRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMI
SAISQAEDPESAARKFREEIQTYKTG
3D structure
PDB2tps Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution.
ChainB
Resolution1.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R59 S130 K159
Catalytic site (residue number reindexed from 1) R51 S122 K151
Enzyme Commision number 2.5.1.3: thiamine phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D93 D112 D85 D104
BS02 TPS B I31 Q57 R59 H107 S130 T156 T158 K159 I186 G188 M207 I208 S209 I23 Q49 R51 H99 S122 T148 T150 K151 I178 G180 M199 I200 S201
BS03 POP B R59 K61 D93 G109 S130 K159 R51 K53 D85 G101 S122 K151
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004789 thiamine-phosphate diphosphorylase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:2tps, PDBe:2tps, PDBj:2tps
PDBsum2tps
PubMed10350464
UniProtP39594|THIE_BACSU Thiamine-phosphate synthase (Gene Name=thiE)

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