Structure of PDB 2rf9 Chain B

Receptor sequence
>2rf9B (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEKIPVAIKELRANKEIL
DEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIG
SQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAK
LLGEYHAGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD
GIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELII
EFSKMARDPQRYLVIQGDE
3D structure
PDB2rf9 Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
ChainB
Resolution3.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D813 A815 R817 N818 D831 G850
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145 G158
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B W881 T885 E904 K905 G906 E907 R908 P910 Q911 P913 I917 V924 W927 M928 W189 T193 E212 K213 G214 E215 R216 P218 Q219 P221 I225 V232 W235 M236
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2rf9, PDBe:2rf9, PDBj:2rf9
PDBsum2rf9
PubMed18046415
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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