Structure of PDB 2rba Chain B

Receptor sequence
>2rbaB (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
TLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQ
LNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKY
QPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSS
SARCAQFPRAQDKVHYYIKLKDLRDQLKGIER
3D structure
PDB2rba Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.
ChainB
Resolution2.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H151
Catalytic site (residue number reindexed from 1) H29
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B G231 K232 P270 S271 R275 C276 A277 Q278 G109 K110 P148 S149 R153 C154 A155 Q156
BS02 dna B G156 A274 R275 C276 A277 P280 G34 A152 R153 C154 A155 P158
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:2rba, PDBe:2rba, PDBj:2rba
PDBsum2rba
PubMed18587051
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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