Structure of PDB 2r8j Chain B

Receptor sequence
>2r8jB (length=509) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MSKFTWKELIQLGSPSKAYESSLACIAHIDMNAFFAQVEQMRCGLSKEDP
VVCVQWNSIIAVSYAARKYGISRMDTIQEALKKCSNLIPIHTAVFKKGED
FWQYHDGCGSWVQDPAKQISVEDHKVSLEPYRRESRKALKIFKSACDLVE
RASIDEVFLDLGRICFNMLMFDNEYELTGDLKLKDALSNIREAFIGGNYD
INSHLPLIPEKIKSLKFEGDVFNPEGRDLITDWDDVILALGSQVCKGIRD
SIKDILGYTTSCGLSSTKNVCKLASNYKKPDAQTIVKNDCLLDFLDCGKF
EITSFWTLGGVLGKELIDVLDLPHENSIKHIRETWPDNAGQLKEFLDAKV
KQSDYDRSTSNIDPLKTADLAEKLFKLSRGRYGLPLSSRPVVKSMMSNKN
LRGKSCNSIVDCISWLEVFCAELTSRIQDLEQEYNKIVIPRTVSISLKTK
SYEVYRKSGPVAYKGINFQSHELLKVGIKFVTDLDIKGKNKSYYPLTKLS
MTITNFDII
3D structure
PDB2r8j Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
ChainB
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B I154 V311 R456 I154 V311 R456
BS02 dna B W56 R73 M74 S394 M395 M396 N398 R426 W56 R73 M74 S394 M395 M396 N398 R426
BS03 CA B D30 D155 E156 D30 D155 E156
BS04 CA B D30 M31 D155 D30 M31 D155
BS05 DCP B D30 N32 A33 F34 F35 I60 Y64 R67 R73 D155 K279 D30 N32 A33 F34 F35 I60 Y64 R67 R73 D155 K279
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:2r8j, PDBe:2r8j, PDBj:2r8j
PDBsum2r8j
PubMed17991862
UniProtQ04049|POLH_YEAST DNA polymerase eta (Gene Name=RAD30)

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