Structure of PDB 2r84 Chain B

Receptor sequence
>2r84B (length=313) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
MKVRIATYASHSALQILKGAKDEGFETIAFGSSKVKPLYTKYFPVADYFI
EEKYPEEELLNLNAVVVPTGSFVAHLGIELVENMKVPYFGNKRVLRWESD
RNLERKWLKKAGIRVPEVYEDPDDIEKPVIVKGYFLAKDPEDFWRKAEIQ
IQEYVLGVPVYPHYFYSKVREELELMSIDRRYESNVDAIGRIPAKDQLEF
DMDITYTVIGNIPIVLRESLLMDVIEAGERVVKAAEELMGGLWGPFCLEG
VFTPDLEFVVFEISARIVAGTNIFVNGSPYTWLRYDRPVSTGRRIAMEIR
EAIENDMLEKVLT
3D structure
PDB2r84 Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.23: formate--phosphoribosylaminoimidazolecarboxamide ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B P116 I130 K132 Y142 E174 Y175 V176 F282 P116 I130 K132 Y134 E153 Y154 V155 F261
BS02 AMZ B S10 H11 G70 S71 H75 R202 V229 N232 A290 S10 H11 G70 S71 H75 R181 V208 N211 A269
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006188 IMP biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2r84, PDBe:2r84, PDBj:2r84
PDBsum2r84
PubMed18069798
UniProtQ8U0R7|PURP_PYRFU 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase (Gene Name=purP)

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