Structure of PDB 2r6y Chain B

Receptor sequence
>2r6yB (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSSMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
SVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKS
LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMPLYDLLLEMLD
3D structure
PDB2r6y Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LLC B L346 T347 A350 D351 E353 W383 L387 F404 M421 I424 H524 L525 L30 T31 A34 D35 E37 W67 L71 F88 M105 I108 H206 L207 MOAD: Ki=0.32nM
BindingDB: IC50=120nM
External links
PDB RCSB:2r6y, PDBe:2r6y, PDBj:2r6y
PDBsum2r6y
PubMed18474858
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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