Structure of PDB 2r6w Chain B

Receptor sequence
>2r6wB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKR
VPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFST
LKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYPLYDLLLEMLDA
3D structure
PDB2r6w Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LLB B M343 L346 T347 A350 D351 E353 L354 L387 F404 M421 I424 H524 L525 L536 M30 L33 T34 A37 D38 E40 L41 L74 F91 M108 I111 H209 L210 L213 MOAD: Ki=0.44nM
External links
PDB RCSB:2r6w, PDBe:2r6w, PDBj:2r6w
PDBsum2r6w
PubMed18474858
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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